The Chelator in RDC (Radionuclide Drug Conjugate) is used to link the radionuclide and the targeting molecule in order to integrate the targeting and effectiveness of RDC. A number of chelators are now applied in the conjugation process.
Rdcthera offers chelators screening and synthesis services, for lateral chelator conjugation services, including covalently binding antibodies, small molecules, and peptides to metal ions.
Chelation is a type of bonding of metal ions to other molecules, forming multiple bonded between the ligand and the central metal atom. The coordination atoms in chelators are oxygen and nitrogen as the most common, followed by sulfur, as well as phosphorus, and arsenic. Before radionuclide can be used for clinical applications, there is a need to seclude the free radionuclide from aqueous solution by chelators to prevent the trans-chelation and hydrolysis processes. As a result, the chelator is widely applied in novel conjugated drugs, especially essential for RDC, which connects the radionuclide and the delivery part.